Chronic toxicity testing

Scientists of Toxi-Coop have many years’ expertise in the successfull execution of chronic toxicological tests.

Some of the most important species and routes are the following:


Species: rat, rabbit, mouse, guinea pig, dog, mini-pig, …


Routes: oral (po; gavage, dietary), intravenous, intramuscular, ocular, intranasal, intratracheal, inhalation, …


28-days repeated dose studies

OECD 407 Repeated Dose 28day Oral Toxicity Study in Rodents

OECD 410 Repeated Dose Dermal Toxicity 21 to 28-day


90-days repeated dose studies

OECD 408 Repeated Dose 90day Oral Toxicity Study in Rodents

OECD 409 Repeated Dose 90day Oral Toxicity Study in Non-Rodents

OECD 411 Subchronic Dermal Toxicity by 90-day


Combined repeated dose / reproduction study
OECD 422 Combined Repeated Dose Toxicity Study with the Reproduction and Developmental Toxicity Screening

Chronic / carcinogenicity studies

OECD 451 Carcinogenicity Studies
OECD 452 Chronic Toxicity Studies
OECD 453 Combined Chronic Toxicity and Carcinogenicity Studies
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