ICH S7A and S7B guidelines for the conduct of safety pharmacology evaluations recommend a core battery of studies on three vital organ systems (cardiovascular, respiratory and central nervous system) to assess the potential risks of novel pharmaceuticals for human use.
Toxi-Coop is capable to perform the studies required in ICH core battery that contains the following measurements after single or repeated exposure:
Cardiovascular system
Telemetric measurement on dogs or using EMKA ECGTunnel measuring system in conscious rats
• Blood pressure
• Heart rate
• Electrocardiograms (ECGs)
• New electrophysiology testing method on Zebrafish
(ECG, QT-prolongation with small amount of the compound)
Respiratory system
• Respiratory rate
• Tidal volume (plethysmograph measurement, EMKA system)
Central nervous system (CNS)
• Functional observation battery (FOB)
• Modified Irwin system
• Motor activity measurement with TSE LABMASTER
• Body temperature
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