Analytical method development / validation

Analytical methods – developed by or implemented at TOXI-COOP – are validated to assure that the analytical procedure is fit for the intended purpose: measures attribute(s) of a test item with the needed specificity/selectivity, accuracy, precision over the reportable range.

Regulatory guidance for the validation of analytical procedures are appropriately chosen to meet study requirements.

Analytical methods used at TOXI-COOP include:

–        HPLC-UV, -FL, -DAD

–        HPLC-MS

–        GC-FID

–        GC-MS

–        ICP-OES

–        UV-VIS Spectrophotometry

–        TOC Analysis

–        Gravimetry

–        Titrimetry

Guidelines and literature:

–        https://www.ema.europa.eu/en/ich-q2r2-validation-analytical-procedures-scientific-guideline

–        https://food.ec.europa.eu/system/files/2023-04/pesticides_mrl_guidelines_2020-12830.pdf

–        https://publications.iupac.org/pac/2002/pdf/7405×0835.pdf

–       https://food.ec.europa.eu/system/files/2019-03/pesticides_ppp_app-proc_guide_phys-chem-ana_3030.pdf